Copper-Associated Liver Disease: More Common than You Think
نویسنده
چکیده
There is increasing recognition that inflammatory liver disease in dogs is associated with abnormal hepatic copper (Cu) concentrations. Abnormal hepatic Cu accumulation results as either a primary metabolic defect in Cu metabolism unique to some breeds or as a secondary event associated with chronic hepatic cholestasis resulting in a decrease in biliary excretion of hepatic Cu. Abnormal hepatic copper can also accumulate in the liver secondary to increased dietary intake. Regardless of the cause at a certain concentration Cu contributes to hepatocellular damage.
منابع مشابه
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